Yes, please refer to this document for doing so:
MP Port Change
These are the keys you will need to add \ edit. PLEASE back up what you have now prior to changing anything. These are examples are for 64 bit machines.
Primary - controlling other machines:
WinKey + R, regedit, enter. Navigate to the following using the name of the Secondary machine you want to connect to; SDROHAN-TEST is the Secondary MP machine in this example
[HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Stardock\Multiplicity2\Machines\SDROHAN-TEST]
"Name"="SDROHAN-TEST"
"DisplayName"="SDROHAN-TEST"
"DynamicIP"="1"
"Address"="10.8.15.109"
"Passkey"="1101"
"LastWorking"="10.8.15.109"
"Port"="17"
Note the addition of the string value Port=17. You can choose what ever port you like here (excluding the know commonly used ones of course).
Primary - What it itself uses:
[HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Stardock\Multiplicity2\Security]
[HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Stardock\Multiplicity2\Security\Ports]
"OverridePort"="1"
"OverridePortPort"="17"
"OverridePortPort2"="55"
OverridePortPort2 is the clipboard port. Again, use any port you like here.
Secondary:
[HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Stardock\Multiplicity2\Security]
[HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Stardock\Multiplicity2\Security\Ports]
"AllowNonRoute"="1"
"OverridePort"="1"
"OverridePortPort"="17"
"OverridePortPort2"="55"
OverridePortPort2 is the clipboard port. Again, use any port you like here.
Running a command prompt as admin and netstat -a will show that it is now listening on the new ports